The plot of the movie is the life of a neurosurgeon, Dr. Stephen Strange, who is an arrogant, yet highly intelligent, neurosurgeon, but then he is involved in a car crash, which seriously mutilates both hands. Strange is desperate to be healed and drives to Kathmandu where he meets the Ancient One who is portrayed by Tilda Swinton.
It is through her that Strange finds the secret world of magic and other dimensions. He gets to know about the mystical organization that defends earth against the dark powers that threaten reality. Training on the magical arts, Strange has to deal with Kaecilius (played by Mads Mikkelsen), the one who is a former student who wants to cause disorder by joining the Earth to the Dark Dimension of Dormammu.